Hi,
It's possible yes. There are two ways:
1. The easy way: Go in System->Emails and edit your order status notification email. There you can add an if statement in order to display different things in the email based on the status, like that:
if($data->order_status=="confirmed"){
echo 'Your order is confirmed';
}elseif($data->order_status=="cancelled"){
echo 'Your order is cancelled';
}
2. The hard way: You need to copy the files of the email in the folder media/com_hikashop/mail and also the corresponding configuration entries in the table hikashop_config. Then, build a hikashop plugin implementing the onAfterOrderUpdate method and set the $email variable to false in there so that the normal email is not sent by hikashop and then add your own code to load your email and send it, like it's done in the save function of the order class in the file administrator/components/com_hikashop/classes/order.php
I would recommend to go with option 1...