Hi,
Yes it is possible to have two part in the shop, you can create two different categories of products, one for "nl" and another for "en". Then fill the products in the correct category with the correct language. and create many menus / modules for each language as for the default Joomla menus.
You can too create different payment / shippings methods restricted to one category, etc.
This way you will have a multilangue website without FaLang or JoomFish.
The only issue is for the items stock. You have to have two separate stocks, or manage manually the stocks, or create a plugin to change dynamically the stock of the item in "en" if one has been bought in "nl" for example.