Restrict shipping by postcode exclusion

What I want to do is simple:

Allow shipping across the whole of the uk except for a few specific postcodes.

I do not want to create hundreds of replicated shipping options - one for every uk postal area except the one that is disallowed. I just want to specify that the shipping methods are disallowed for a particular post code.

i.e. restrict by exclusion rather than inclusion.

Is there anyway I can do this easily?

Best wishes,

Jonathan