Hi,
Sure. Edit the file "address" of the view "checkout" via the menu Display>Views and change the line:
<input class="hikashop_checkout_shipping_same_address inputbox" <?php echo $checked; ?>type="checkbox" id="same_address" name="same_address" value="yes" alt="Same address" onclick="<?php echo $onclick; ?>" />
to:
<input class="hikashop_checkout_shipping_same_address inputbox" <?php echo $checked; ?>type="checkbox" id="same_address" name="same_address" disabled="disabled" value="yes" alt="Same address" onclick="<?php echo $onclick; ?>" />